Liana Tsenova

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Liana Tsenova, MD

Dr. Tsenova joined City Tech in 2008. Currently she is an Associate Professor at the Biological Sciences Deapartment. She has received her M.D. degree and specialty in Microbiology and Immunology from the Medical Academy of Sofia, Bulgaria. In 1993 Dr. Tsenova came to the Rockefeller University, NY with an international John Fogarty fellowship. Later on she continued her postdoctoral training there, at the Laboratory of Cellular Physiology and Immunology. She works as an Adjunct faculty at Rutgers the State University of New Jersey. Her research is focused on the host-pathogen interaction in tuberculosis and other infectious diseases, role of cytokines in the immune response, design of immunomodulatory therapy, and evaluation of new anti-TB candidate vaccines. At City Tech Dr. Tsenova serves at the Coordination of Student Research Committee and works as a mentor for undergraduate students. She is interested in collaborative interdisciplinary projects, combining microbiology and infectious diseases with mathematics, to address unresolved epidemiologic, ecologic and healthcare problems. She has co-authored more than 50 publications in peer-reviewed scientific journals and chapters.

At City Tech Dr. Tsenova teaches Microbiology and General Biology I. She currently serves as the Bachelor of Science in Radiological Science (BSRS) Faculty Advisor at the Department of Radiologic Technology and Medical Imaging. Dr. Tsenova is the PI/Project Director of the Bridges to the Baccalaureate Program at City Tech, funded by NIH.


  • MD - Medical Academy, Sofia, Bulgaria
    Medical Specialty - Microbiology/Immunology,
    Department of Microbiology, Medical Academy, Sofia, Bulgaria

Courses Taught at City Tech:

  • Bio 1101 - Biology I
  • Bio 3302 - Microbiology

Research Interests:

  • Host-Pathogen interactions in tuberculosis
  • Role of cytokines in the immune response
  • Design of immunomodulatory therapy in tuberculosis
  • Evaluation of new candidate vaccines and adjuvants, using experimental animal models
  • Defining the host-pathogen determinants of latency in tuberculosis

Recent Publications:

  • Subbian S., N. Bandyopadhyay, L. Tsenova, P. O’Brien, V. Khetani, et al. Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits. Cell Commun Signal. 2013 Aug 19;11(1):60.
  • Subbian S., O’Brien P., Kushner NL, Yang G., Tsenova L., Peixoto B.,F allows D. and Kaplan G. Molecular Immunologic Correlates of Spontaneous Latency in a Rabbit Model of Pulmonary Tuberculosis. Cell Commun Signal. 2013 Feb 28;11(1):16.\
  • Subbian S., L. Tsenova, P. O’Brien, G. Yang, N. Lynn Hart, S. Parsons, B. Peixoto, D. Fallows and G. Kaplan. Spontaneous Latency in a Rabbit Model of Pulmonary Tuberculosis. Am J Pathol. Am J Pathol. 2012 Sep 5.
  • Subbian S., L. Tsenova, G Yang, P O’Brien, S Parsons, B Peixoto, L Taylor, D Fallows and G Kaplan. Chronic Pulmonary Cavitary Tuberculosis in Rabbits: a Failed Host Immune Response. Open Biology. 2011, 1: 110016.
  • Ghosh-Dastidar U. and L. Tsenova. Bio-Math Mapping: Water Quality Analysis of Hudson River and Gowanus Canal, A SENCER-based Summer Project. Science Education and Civic Engagement : An International Journal. 4:1 winter 2012 
  • Subbian S., L. Tsenova, P. O’Brien, G. Yang, M. Koo, D. Fallows, V. Dartois, G. Muller and G. Kaplan. Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog. 2011 Sep;7(9):e1002262. Epub 2011 Sep 15.
  • Subbian S., L. Tsenova, P. O’Brien, G. Yang, M. Koo, B. Peixoto, D. Fallows, J. Zeldis, G. Muller and G. Kaplan. PDE4 inhibition combined with INH treatment of rabbits with pulmonary tuberculosis reduces macrophage activation and lung pathology. Am J Pathol. 2011 Jul;179(1):289-301.
  • Singhal. A, Aliouat E, Hervé M, Mathys V, Kiass M, Creusy C, Delaire B, Tsenova L, Bertout L, Camacho L, Foo D, Tay H.C, Yee S. J, Boukhouchi W, Romano M, Mathema B, Dartois V, Kaplan G, Bifani P. Experimental tuberculosis in the Wistar rat: A model for protective immunity and control of infection, PLoS One. 2011 Apr 12;6(4):e18632.
  • Koo M., C. Manca, G. Yang, P. O’Brien, N. Sung, L. Tsenova, S. Subbian, D. Fallows, G. Muller, S. Ehrt and G. Kaplan. Phosphodiesterase 4 Inhibition Reduces Innate Immunity and Improves Clearance of Mycobacterium tuberculosis in the Lungs of Infected Mice. PLoS ONE, Feb 2011:6(2)
  • Kana BD, G.L. Abrahams, N. Sung, D.F. Warner, B.G. Gordhan, E.E. Machowski, L. Tsenova, J.C. Sacchettini, N. G. Stoker, G. Kaplan and V. Mizrahi. Role of the DinB Homologs Rv1537 and Rv3056  in Mycobacterium tuberculosis. J Bacteriol. 2010 Apr;192(8):2220-7. Epub 2010 Feb 5.

Peer-Reviewed Scholarly Books (Chapters):

  • G. Kaplan and L. Tsenova. Chapter 7: Pulmonary tuberculosis in the rabbit, in:  A Colour Atlas of Comparative Pulmonary Tuberculosis Histopathology. Ed.  F. J. Leong, V. Dartois & T. Dick. CRC Press, Taylor &Francis Group 2010.
  • J. L. Flynn, L. Tsenova, A. Izzo, G. Kaplan. Experimental Animal Models of Tuberculosis. In: SHE Kaufmann, E. Rubin, W. Britton and P. van Helden eds. Handbook of Tuberculosis: Immunology and Cell Biology. WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim, 2008.
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