Liana Tsenova

Office:
» Pearl Building 313 (P-313)

Phone:
» 718.260.5960

E-mail:
» ltsenova@citytech.cuny.edu

Liana Tsenova

Education:

• MD - Medical Academy, Sofia, Bulgaria
  Medical Specialty - Microbiology/Immunology,
  Department of Microbiology, Medical Academy, Sofia, Bulgaria

Courses Taught at City Tech:

• Bio 1101 - Biology I
• Bio 3302 - Microbiology

Research Interests:

• Host-Pathogen interactions in tuberculosis
• Role of cytokines in the immune response
• Design of immunomodulatory therapy in tuberculosis
• Evaluation of new candidate vaccines and adjuvants, using experimental animal models
• Defining the host-pathogen determinants of latency in tuberculosis

Recent Publications:

• Tsenova L., Y., R. Harbacheusky, A.L Moreira, E. Ellison, W. Dalemans, M.R. Alderson, S. Reed, A.W. Skeiky, and G. Kaplan. Evaluation of the MTB72F Polyprotein Vaccine in a Rabbit Model of Tuberculous Meningitis. Infect Immun. 2006; Volume 74 (4):2392-2401
• Tsenova L., R. Harbacheusky, E. Ellison, C. Manca and G. Kaplan. Aerosol Exposure system for rabbits: Application to M. tuberculosis infection. Applied Biosafety. 2006; 11(1):7-14.
• Tsenova L., R. Harbacheusky, N. Sung, E. Ellison, D. Fallows and G. Kaplan. BCG Vaccination Confers Poor Protection against M. tuberculosis HN878-induced Central Nervous System Disease. Vaccine. 2007 Jul 9;25(28):5126-32. Epub 2006 Nov 27.
• B. D. Kana, B. G. Gordhan, K. J. Downing, N. Sung, G. Vostroktunova, E. E. Machowski, L. Tsenova, M. Young, A.  Kaprelyants, G. Kaplan, V. Mizrahi. The resuscitation-promoting factors of Mycobacterium tuberculosis are required for virulence and resuscitation from dormancy but are collectively dispensable for growth in vitro. Mol Microbiol. 2008 Feb;67(3):672-84.
• Sinsimer D , Huet G, Manca C, Tsenova L, Koo MS, Kurepina N, Kana B, Mathema B, Marras SA, Kreiswirth BN, Guilhot C, Kaplan G. The phenolic glycolipid of Mycobacterium tuberculosis differentially modulates the early host cytokine response but does not in itself confer hypervirulence. Infect Immun. 2008 Jul;76(7):3027-36. Epub 2008 Apr 28
• Koo M., N. Sung, C. Manca, L. Tsenova, D. Fallows and G. Kaplan. Immunomodulation with CC-3052 accelerates antibiotics efficacy in M. tuberculosis-infected mice. Submitted in J. Exp Medicine
• M. Kim,H.C. Wainwright, M. Locketz, L. Bekker, G. B. Walter, C. Maske, C. Dittrich, A. Visser, W. Wang, F. Hsu, U. Wiehart, L. Tsenova, G. Kaplan, D. G. Russel. Dysregulated lipid metabolism drives the progression of human tuberculous granulomas. Submitted in PNAS.
• Kana BD, G.L. Abrahams, N. Sung, D.F. Warner, B.G. Gordhan, E.E. Machowski, L. Tsenova, J.C. Sacchettini, N. G. Stoker, G. Kaplan and V. Mizrahi. Role of the Y-family DNA-Polimerase-Encoding dinB Homologs, Rv1537 and Rv3056, in Mycobacterium tuberculosis. In press, J. Bacteriology

Monographs and Chapters:

• Immunology - A Short Course, Second Edition - Eli Benjamini, Sidney Leskowitz; Eds. Wiley-Liss, Publishers, 1992. - Translated into Bulgarian, 1994.
• Tsenova L., V. H. Freedman and G. Kaplan. Experimental Tuberculous Meningitis. In: Peterson P. Remington J.S. eds.  New Concepts in the Immunopathology of CNS Infections. Malden, MA: Blackwell Science, 2000.
• Jaeger J. R., S. G. Shami and L. Tsenova. Directed-Flow Aerosol Inhalation Systems: Applications to Pathogens and Highly Toxic Agents. pp.73-90 In: Inhalation Toxicology, Second Edition. Boca Raton, FL: Taylor &Francis Group, LLC, 2005.
• J. L. Flynn, L. Tsenova, A. Izzo, G. Kaplan. Experimental Animal Models of Tuberculosis. In: SHE Kaufmann, E. Rubin, W. Britton and P. van Helden eds. Handbook of Tuberculosis: Immunology and Cell Biology. WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim, 2008.