Alberto Martínez


Office:
» Pearl Building 613 (P-613)


Phone:
» 718.260.5855


E-mail:
» amartinez
   @citytech.cuny.edu




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Alberto Martínez, Assistant Professor

Courses Taught:

CHEM 1000, CHEM 1110, CHEM 1110L, CHEM 1210L

Education:

Post-doctoral fellowship, Brooklyn College, City University of New York,
2006-2012
Post-doctoral fellowship, Virginia Commonwealth University/Massey Cancer Center, 2010-2011
PhD, University of Barcelona, Chemistry, 2005
MS, University of Barcelona, Chemistry, 2001
BS, University of Barcelona, Chemistry, 2000

Research Interests:

Design and synthesis of small molecules as ionophores for the understanding of the role that metal ions play in Alzheimer's disease
Chemotherapy of Malaria: Synthesis and mechanistic studies of organometallic ruthenium compounds of chloroquine and organic/organometallic 1,2,4-trioxane derivatives
Design and synthesis of Ru(II) and Ru(III) complexes of azole molecules with sterol biosynthesis inhibitor (SBI) properties for the treatment of trypanosomatid diseases
Synthesis and mechanistic studies of Pt(II) and Pt(IV) coordination complexes with antitumor properties

Publications:

Martínez, A.; Carreon, T.; Anzellotti, A.; Sánchez, A.; Tyan, M.; Sattler, A.; Herrera, L.; Maldonado, R.A.; Sánchez-Delgado, R.A. “Searching for New Chemotherapies for Tropical Diseases: Ru-Clotrimazole Complexes Display High in vitro Activity Against Leishmania major and Trypanosoma cruzi and Low Toxicity Toward Normal Mammallian Cells”, J. Med. Chemistry, 2012, 55, 3867-3877.

Glans, L.; Ehnbom, A. ; de Kock, C. ; Martínez, A. ; Estrada, J. ; Smith, P.J. ; Haukka, M. ; Sánchez-Delgado, R.A. ; Nordlander, E. “Ruthenium(II) Arene Complexes With Chelating Chloroquine Analogue Ligands: Synthesis, Characterization and in vitro Antimalarial Activity”, Dalton Trans. 2012, 41, 2764-2773.

Benedetti, B.T. ; Peterson, E.J. ; Kabolizadeh, P. ; Martínez, A. ; Kipping, R. ; Farrell, N.P. “Effects of Noncovalent Platinum Drug-Protein Interactions on Drug Efficacy: Use of Fluorescent Conjugates as Probes for Drug Metabolism”, Mol. Pharm. 2011, 8(3), 940-948

Navarro, M.; Castro, W.; Martínez, A.; Sánchez-Delgado, R.A. “The Mechanism of Antimalarial Action of [Au(CQ)(PPh3)]PF6 : Structural Effects and Increased Drug Lipophilicity Enhance Heme Aggregation Inhibition at Lipid/Water Interfaces”, J. Inorg. Biochem. 2011, 105, 276-282.

Martínez, A.; Suárez, J.; Shaund, T.; Magliozzo, R. ; Sánchez-Delgado, R.A. “Interactions of Arene-Ru(II)-Chloroquine Complexes of Known Antimalarial and Antitumor Activity with Human Serum Albumin (HSA) and Transferrin”, J. Inorg. Biochem. 2011, 105, 39-45

Martínez, A.; Rajapakse, C.S.K.; Aguilera, R.; Lema, C.; Varela, A.; Sánchez-Delgado, R.A. “Arene-Ru(II)-Chloroquine Complexes Interact With DNA, Induce Apoptosis On human lymphoid cell Lines and Display low Toxicity to Normal Mammalian Cells”,  J. Inorg. Biochem. 2010, 104, 967-977

Galindo, M.A.; Amantia, D.; Martínez, A.; Clegg, W.; Harrington, R.W.; Moreno, V.; Houlton, A. “Reactions of Pd(II) with Chelate-Tethered 2,6-diaminopurine Derivatives: N3 coordination and reaction of the Purine System”, Inorg. Chem. 2009, 48, 11085-11091

Galindo, M.A.; Amantia, D.; Martínez, A.; Clegg, W.; Harrington, R.W.; Moreno, V. ; Houlton, A.  “Probing Metal-Ion Purine Interactions at DNA Minor-Groove Sites”, Inorg. Chem. 2009, 48, 10295-10303

Jiménez, S.; López, J.A.; Ciriano, M.A.; Tejel, C.; Martínez, A.; Sánchez-Delgado, R.A., “Selective Hydrogenation of Cynnamaldehyde and Other a,b-unsaturated Substrates Catalyzed by Rhodium and Ruthenium Complexes”, Organometallics, 2009, 28(11), 3193-3202

Martínez, A.; Rajapakse S.K., C.; Jalloh, D.; Dautriche, C.; Sánchez-Delgado, R.A. “The Antimalarial Activity of Ru-Chloroquine Complexes Against Resistant P. falciparum is related to Lipophilicity and Heme Aggregation Inhibition Ability Near Water-Octanol Interfaces”, J. Biol. Inorg. Chem. 2009, 14, 863-871

Rajapakse, C.S.K. ; Martínez, A. ; Naoulou, B. ; Jarzecki, A.A. ; Suárez, L. ; Deregnaucourt, C.; Sinou, V.; Schrével, J.; Musi, E. ; Ambrosini, G. ; Schwartz, G.K.; Sánchez-Delgado, R.A. “Synthesis, Characterization, and in vitro Antimalarial and Anticancer Activity of New Ruthenium(II) Complexes of Chloroquine”, Inorg. Chem. 2009, 48, 1122-1131.

Shaik, N; Martínez, A.; Augustin, I; Giovinazzo, H.; Varela, A; Aguilera, R; Sanau, M; Aguilera, R.J.; Contel, M. “Synthesis of Apoptosis-Inducing Iminophosphorane Organogold(III) Complexes and Study of Their Interactions with Biomolecular Targets”,  Inorg. Chem. 2009, 48, 1577-1587

Martínez, A.; Moreno, V.; Sanglas, L.; de Llorens, R.; Avilés, F.X.; Lorenzo, J. “Study by HPLC-MS of the Interaction of Platinum Antitumor Complexes with Potato Carboxypeptidase Inhibitor (PCI)”, Bioorg. Med. Chem. 2008, 16, 6832-6840.

Martínez, A.; Rajapakse S.K., C.; Naoulou, B.; Kopkalli, Y. ; Davenport, L.; Sánchez-Delgado, R.A. “The Mechanism of Antimalarial Action of the Ruthenium(II)-Chloroquine Complex [RuCl2(CQ)]2”, J. Biol. Inorg. Chem. 2008, 13, 703-712.

Martínez, A.; Lorenzo, J.; Font-Bardía, M.; Solans, X.; Prieto, M.J.; Moreno, V. “Influence of the Position of Substituents in the Cytotoxic Activity of Trans Platinum Complexes with Hydroxymtehylpyridines”, Bioorg. Med. Chem. 2007, 15, 969-979

Stehlikova, K; Kasparkova, J.; Novakova, O.; Martínez, A.; Moreno, V.; Brabec, V. “Recognition of DNA Modified by Trans-[PtCl2NH3(4-hydroxymethylpyridine)] by Tumor Supresor Protein p53 and Character of DNA Adducts of this Cytotoxic Complex”,  The FEBS Journal, 2006, 273, 301-314

Martínez, A.; Lorenzo, J.; Prieto, M.J.; de Llorens, R.; Font-Bardía, M.; Solans, X.; Avilés, F.X.; Moreno, V., “Synthesis, Characterization and Biological Activity of  trans-Platinum(II) and trans-Platinum(IV) Complexes with 4-Hydroxymethylpyridine”, ChemBioChem, 2005, 6, 2068-2077.

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