» Pearl 313 (P-313)
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- Microbiology, Human Anatomy and Physiology, General Biology;
- PhD, CUNY Graduate Center, Molecular, Cellular and Developmental Biology;
- MD, China Medical University, Clinical Medicine;
- Intracellular protein degradation through the ubiquitin-proteasome pathway is a highly complex and tightly regulated process. It plays important roles in a variety of basic cellular processes. Among them are the regulation of cell cycle and division, involvement in the cellular response to stress, modulation of cell surface receptors, DNA repair, biogenesis of organelles and regulation of the immune and inflammatory responses. Aberrations in protein degradation through the ubiquitin-proteasome pathway have been implicated in the pathogenesis of many diseases, such as cancer, Parkinson's Disease, Alzheimer's Disease, etc. Our research mainly focused on the molecular basis underlying the involvement of this pathway in the pathogenesis of neurodegenerative disorders such as Parkinson's diseas and Alzheimer's disease. Further studies in this field may bring us new insights into the pathogenesis of these diseases and provide therapeutic alternatives for these devastating disorders.
- Zongmin Li, Marlon Jansen, Lavonne Hunter, Laura Salvatierra, Sneha Mathews And Maria E. Figueiredo-Pereira (2004) "The Neurotoxic Prostaglandin J2 Enhances Cyclooxygenase-2 Expression In Neuronal Cells Through The P38mapk Pathway: A Death Wish?" Journal of Neuroscience Research 2004 78 824 – 836.
- Zongmin Li, Francesco Melandri, Ingrid Berdo, Marlon Jansen, Lavonne Hunter, Saundrene Wright, Danielle Valbrun and Maria E. Figueiredo-Pereira (2004) "Prostaglandin J2 exerts a positive feedback on cyclooxygenase-2 expression and inhibits the neuronal ubiquitin hydrolase uch-l1: a culprit in neurodegeneration?" Biochemical Biophysical Research Communications 2004 JULY 9; 319(4):1171-80.
- Zongmin Li, Lisette Arnoud, Patricia Rockwell and Maria Figueiredo-Pereira (2004) "A single proteasome mutation triggers aggregation of ubiquitinated proteins in stressed neuronal cells" Journal of Nneurochemistry, July 2004; 90(1):19-28.
- Zongmin Li, Marlon Janson, Sha-Ron Pierre and Maria Figueiredo-Pereira (2003) "Neurodegeneration: linking ubiquitin/proteasome pathway impairment with inflammation", International Journal of Biochemistry and Cell Biology, Medicine in Focus, 35/5 pp. 547-552.
- Maria Figueiredo-Pereira, Zongmin Li, Marlon Jansen, Patricia Rockwell (2002) "N-acetylcysteine and celecoxib lessen cadmium cytotoxicity which is associated with cyclooxygenase-2 up-regulation in mouse neuronal cells" J. BIOL. CHEM. 277(28): 25283-252899.