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Biological Sciences

Karthikeyan
Laina Karthikeyan
Assistant Professor
P-313
718.260.5953
lkarthikeyan@citytech.cuny.edu

Courses Taught:

  • BY100, BY100L, BY101, BY101L & BY 524

Education:

  • PhD, New York University Medical Center, Molecular Biology
  • MA, Boston University, Molecular Biology
  • MS, Bangalore University, India, Zoology

Research Interests:

  • My research focus is on the molecular basis of neurodegenerative diseases like Dystonia, and Parkinson’s. Deletion of a single glutamate in torsinA correlates with early-onset Dystonia, the most severe form of a neurological disorder, characterized by uncontrollable muscle contractions. Symptoms usually begin around age 12. The disorder typically begins in just one part of the body, but it eventually spreads to other regions and leaves individuals severely disabled and confined to a wheelchair. My aim is to find out, how the abnormal version of the protein torsinA, leads to the disease.

PUBLICATIONS:

  1. Shashidharan, P., N. Paris, D. Sandu D, L. Karthikeyan, K. S. McNaught, R. H. Walker and C.W.Olanow. 2004. Overexpression of torsinA in PC12 cells protects against toxicity. J. Neurochem. 2004, 88, 1019-1025.
  2. Karthikeyan, L., M. Flad, M. Engel, B. Meyer-Puttlitz, R. U. Margolis and R. K. Margolis. 1994. Immunocytochemical and in situ hybridization studies of the heparan sulfate proteoglycan, glypican, in nervous tissue. J. Cell Sci. 107:3213-3222.
  3. Grumet, M., P. Milev, T. Sakurai, L. Karthikeyan, M. Bourdon, R. K. Margolis and R. U. Margolis. 1994. Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue. J. Biol. Chem. 269:12142-12146.
  4. Milev, P., D. R. Friedlander, T. Sakurai, L. Karthikeyan, R. K. Margolis, M. Grumet and R. U. Margolis. 1994. Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules. J. Biol. Chem. 127:1703-1715.
  5. Friedlander, D. R., P. Milev, L. Karthikeyan, R. K. Margolis, R. U. Margolis and M. Grumet. 1994. The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/L1/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J. Cell Biol.125: 669-680.
  6. Rauch, U., L. Karthikeyan, P. Maurel, R. U. Margolis and R. K.Margolis. 1992. Cloning and primary structure of neurocan, a developmentally regulated, aggregating chondroitin sulfate proteoglycan of brain. J. Biol. Chem. 267:19536-19547.
  7. Karthikeyan, L., P. Maurel, U. Rauch, R. K. Margolis and R. U. Margolis. 1992. Cloning of a major heparan sulfate proteoglycan from brain and identification as the rat form of glypican. Biochem. Biophys. Res. Commun. 188:395-401.

PRESENTATIONS:

  • Singh, M., Karthikeyan, L., Schaefer, A. E., Estol, C. Sumoylation of torsin A; Annual Biomedical Research Conference For Minority Students, October 15-18, 2003, San Diego, California; abstract published in ABRCMS (2003) p. 394.
  • Karthikeyan, L., Sculerati, N., Kumar, A., Shashidharan P. Glutamate transporter gene expression and localization in neonatal mouse cochlea. Association for Research in Otolaryngology, 20th midwinter research meeting, February 2-6, 1997, St. Petersburg Beach, Florida; abstract published in ARO (1997).
  • Karthikeyan, L., Sculerati, N., Ostrer, H. Cloning of fimbrin cDNAs from the mouse cochlea. Association for Research in Otolaryngology, 19 th midwinter research meeting, February 4-8, 1996, St. Petersburg Beach, Florida; abstract published in ARO (1996) p.152.
  • Grumet, M., Friedlander, D., Milev, P., Sakurai, T., Karthikeyan, L., Flad, M., Margolis, R. K., Margolis, R. U. Interactions of phosphacan, the extracellular region of a receptor-type protein tyrosine phosphatase, with neurons, glia, and neural cell adhesion molecules; Society for Neuroscience, 24th annual meeting, November 13-18, 1994, Miami Beach, Florida; abstract published in Soc. Neurosci. Abstr. (1994), Vol. 20, Part 1, p. 475.
  • Maurel, P., Milev, P., Friedlander, D., Rauch, U., Karthikeyan, L., Flad, M., Grumet, M., Margolis, R. K., Margolis, R. U. Phosphacan, a chondroitin sulfate proteoglycan of nervous tissue which is an extracellular variant of a receptor-type protein tyrosine phosphatase; Federation of European Connective Tissue Societies, 14th Meeting, August 30-September 3, (1994), Lyon, France; abstract published in Program/Abstracts Book, M14.
  • Maurel, P., Milev, P., Karthikeyan, L., Sakurai, T., Flad, M., Engel, M., Friedlander, D., Grumet, M., Margolis, R. K., Margolis, R. U. Phosphacan a nervous tissue-specific chondroitin sulfate proteoglycan which is an extracellular variant of a receptor-type protein tyrosine phosphatase; Gordon Research conference on proteoglycans Proctor Academy July 10-15, (1994), Andover, New Hampshire.
  • Margolis, R. U., Maurel, P., Milev, P., Karthikeyan, L., Friedlander, D., Grumet, M., Margolis, R. K. Structure and function of nervous tissue proteoglycans; American Society for Neurochemistry, 25th meeting, March 5-9, 1994, Albuquerque, New Mexico; abstract published in J. Neurochem. (1994) vol. 62 suppl., p. S30.
  • Maurel, P., Milev, P., Rauch, U., Karthikeyan, L., Grumet, M., Margolis, R .U., Margolis, R .K. Primary structure and functional studies of chondroitin sulfate proteoglycans of brain; American Society for Neurochemistry, 24th annual meeting, March 21-25, 1993, Richmond, Virginia; abstract published in Transact. Amer. Soc. Neurochem. (1993) vol. 24, p. 197.
  • Rauch, U., Karthikeyan, L., Maurel, P., Margolis, R.U., Margolis, R. K. The 1D1 proteoglycan of brain., Society for Neuroscience, 22nd annual meeting, October 25-30, 1992, Anaheim, California; abstract published in Soc. Neurosci. Abstr. (1992), Vol. 18, Part 2, p. 1327.
  • Rauch, U., Karthikeyan, L., Margolis, R. U., Margolis, R. K. The 1D1 proteoglycans: brain-specific members of theversican/aggrecan family. Federation of European Connective Tissue Societies, 13th Meeting, July12-17, (1992), and Davos-Platz, Switzerland.
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