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Biological Sciences

Chakraborty
Dr. Sanjoy Chakraborty
Assistant Professor
P-313
718.260.5968
schakraborty@citytech.cuny.edu

Courses Taught:

  • Biology 101; Anatomy & Physiology (301.1); Anatomy & Physiology (301.2).

Education:

  • PhD in Reproductive Biology/ Biochemistry.
  • MS in Biochemistry

Research Interests:

  • Glycerophosphate acyltransferase (GAT) (EC 2.3.1.15) catalyzes the most significant and committed step in glycerolipid synthesis by converting sn-glycerol 3-phosphate to lysophosphatidic acid. The enzyme has a bimodal distribution in mammalian system - mitochondrial outer membrane and the microsomes. Glycerolipid are essential for cell homeostasis environment, proper membrane functions and the integrity of the cell, facilitate cellular signal transduction and most importantly triacylglycerol synthesis. Most of these functions are affected by the quality of the fatty acyl chains (saturation, length and position); the chain is selected at the first step of glycerolipids biosynthesis by mitochondrial GAT (mtGAT). My research focused on the better understanding of its regulation in vivo at molecular and biochemical level.
  • Published data revealed that Ehrlich Ascites Tumor Cells does not have detectable mtGAT activity; as a result, the cells display randomization of fatty acid distribution in cellular phospholipids. These randomizations surely have an effect on the membrane integrity and their proper biological function. Moreover, the damage or change in the membrane may have relation to their uncontrolled growth. We also studied to answer the intriguing question as to why one major collaborator of a battery of enzymes in lipid biogenesis lost its activity in tumor cells.

Publications and Presentations:

  1. Roy A, Guha N, Veras ID, Chakraborty S, Haldar D. The role of Polymyxin B on rat liver mitochondrial sn-glycerol-3-phosphate acyltransferase (GAT) and its mode of action. Lipids, 2003; Vol. 38 (9): 965-972.
  2. Onorato TM, Chakraborty S, Balija VS, and Haldar D. Mitochondrial glycerol-3-phosphate acyltransferase. Lipids: Glycerolipid Metabolizing Enzymes, Research Signpost, 2002; 43-54.
  3. Sugimoto T, Das H, Imoto S, Murayama T, Gomyo H, Chakraborty S, Taniguchi R, Isobe T, Nakagawa T, Nishimura R, Koizumi T. Quantitation of minimal residual disease in t(8;21)-positive acute myelogenous leukemia patients using real-time quantitative RT-PCR. Am J Hematol, 2000; 64(2): 101-106.
  4. Das H, Koizumi T, Sugimoto T, Chakraborty S, Ichimura T, Hasegawa K, Nishimura R. Quantitation of Fas and Fas ligand gene expression in human ovarian, cervical and endometrial carcinomas using real-time quantitative RT-PCR. Br J Cancer, 2000; 82(10): 1682-1688.
  5. Taniguchi R, Das H, Chakraborty S, Sugimoto T, Hasegawa K, Kono M, Nishimura R. Trophoblastic cells expressing human chorionic gonadotropin genes in peripheral blood of patients with trophoblastic disease. Life Sci, 2000; 66(17): 1593-1601.
  6. Roy T, Chakraborty S, Das H, Chakraborty BN and Bhattacharya AK. In vitro induction of nuclear DNA dispersion of ram spermatozoa. Journal of Basic and Applied Biomedicine, 1995; 3(3): 25-29.
  7. Roy T, Chakraborty S, Karmakar P, Chakraborty BN, and Bhattacharya AK. Heterogeneity in nuclear chromatin dispersion of human spermatozoa in vitro. Institute of Reproductive Medicine Bulletin, 1995; 17: 19-25.
  8. Chakraborty S, Chakraborty TR, Onorato TM, Haldar D. Does estrogen regulate mitochondrial glycerophosphate acyltransferase activity? FASEB J, 2003; 17(4), A581.
  9. Onorato TM, Chakraborty S, Haldar D. Further studies on the regulation of mitochondrial glycerophosphate acyltransferase by casein kinase II. FASEB J, 2003; 17(4), A581.
  10. Veras ID, Chakraborty S, Onorato TM, Haldar D. Further analysis of the lack of mitochondrial glycerophosphate acyltransferase activity in mouse ascites tumor cells. FASEB J, 2003; 17(4), A581.
  11. Chakraborty S, Chakraborty TR, Haldar D. Analysis of the lack of mitochondrial glycerophosphate acyltransferase activity in mouse ascites tumor cells. FASEB J, 2002; 16(4), A538.
  12. Chakraborty S, Roy T, Bhattacharyya AK. In vitro induction of nuclear DNA dispersion of human spermatozoa and cyropreservation. FASEB J, 1999; 13, A1363.
  13. Chakraborty S, Roy T, Bhattacharya AK. Selection of cryoprotective media in relation to seminal characteristics. 3rd National Congress on Assisted Reproductive Technology and Advances in Infertility Management, ISAR Calcutta, India,1997.
  14. Roy T, Chakraborty S, Bhattacharya AK. Toxicity of sperm cells- an eternal problem of ART. 3rd National Congress on Assisted Reproductive Technology and Advances in Infertility Management, ISAR, Calcutta, India, 1997.
  15. Chakraborty S, Roy T, Bhattacharya AK., Vander Ven H. Assessment of integrity of sperm plasma membrane and its possible correlation with the fertilizing ability. International Symposium on Male Contraception - Present and Future, Organized by WHO, New Delhi, India, 1995.
  16. Roy T, Chakraborty S, Bhattacharya AK., Vander Ven, H. Occurrence of superoxide dismutase in human semen - its possible significance. Internatinal Symposium on Male Contraception - Present and Future, Organised by WHO, New Delhi, India, 1995.
  17. Chakraborty S, Bhattacharya AK., Vander Ven H. Young Scientist Symposium on Frontiers in Reproductive Biology Research, Bombay, India, 1995.
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