Ralph R. Alcendor

» Pearl 313 (P-313)

» 718.254.8614

» ralcendor@citytech.cuny.edu

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Ralph R. Alcendor


  • 2007 – PhD - Cell and Molecular Biology, UMDNJ-Graduate School of Biomedical Sciences, Newark, NJ
  • 2000 – Bs. Biology, University of the Virgin Islands, St. Thomas, USVI

Courses Taught at City Tech:

  • Bio 1101 – Biology I
  • Bio 231.1 – Anatomy and PhysiologyI
  • Bio 3302 – Microbiology

Research Focus:

  • Longevity factors
  • Stress resistant mechanisms
  • Cell signaling molecules


  • Ralph R. Alcendor, Shumin Gao, Peiyong Zhai, Daniela Zablocki, Eric Holle, Xianzhong Yu, Bin Tian, Thomas Wagner, Stephen F. Vatner, Junichi Sadoshima. Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart. Circulation Research. 2007, Vol. 100:1512-21.
  • Ieng-Yi Chen, Jacqueline Lypowy, Jayashree Pain, Danish Sayed, Stan Grinberg, Ralph R. Alcendor, Junichi Sadoshima, and Maha Abdellatif. Histone H2A.z Is Essential for Cardiac Myocyte Hypertrophy but Opposed by Silent Information Regulator 2 Journal of Biological Chemistry, Vol. 281, 28, 19369-19377
  • David C Zebrowski, Raph R Alcendor, Lorrie A Kirshenbaum, Junichi Sadoshima. Caspase-3 mediated cleavage of MEKK1 promotes p53 transcriptional activity. Journal of Molecular and Cellular Cardiology May;40(5):605-18
  • Ralph R. Alcendor; Lorrie A. Kirshenbaum; Shin-ichiro Imai; Stephen F. Vatner; and Junichi Sadoshima. Silent Information Regulator 2, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes. Circulation Research 2004;95:971

Meeting Presentations:

  • American Heart Association Scientific Sessions, November 2 - 7, 2007. Alcendor RR, Hong C, Zhai P, Gao S, Sadoshima J. The Longevity Factor Sirt1 Exacerbates LV Dysfunction and Energy Depletion in Response to Pressure Overload. (Oral Presentation)
  • American Heart Association Scientific Sessions, November 12-15, 2006. Alcendor RR, Abdellatif M, Sadoshima J. A longevity factor, silent information regulator 2 (Sir2), protects cardiac myocytes from oxidative stress. (Oral presentation)
  • American Heart Association Scientific Sessions, November 13-16, 2005. Alcendor RR, Hong C, Liu J, Sadoshima J Cardiac Specific Overexpression of Sir2 (Silent information Regulator 2) Induces Anti-Apoptotic and Anti-Aging Effects in Transgenic Mice. (Oral presentation)
  • American Heart Association Scientific Sessions, November 7 - 10, 2004. Alcendor RR, Sadoshima J. Sir2, a Longevity Factor, Protects Cardiac Myocytes from Serum Starvation and Hydrogen Peroxide-Induced Apoptosis. (Oral presentation)
  • American Heart Association Scientific Sessions, November 9-12, 2003. Alcendor RR, Sadoshima J. Inhibition of Class III Histone Deacetylases, Sir2, Induces Apoptosis in Cardiac Myocyte Without Increase in Cell Size. (Oral presentation)
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